ISSN 2415-3060 (print), ISSN 2522-4972 (online)
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JMBS 2019, 4(4): 64–71
https://doi.org/10.26693/jmbs04.04.064
Clinical Medicine

Parameters of Carbohydrate Metabolism and Expression of Liver Steatosis in Patients with Nonalcoholic Fatty Liver Disease and Hypertensive Depending on Lipid Parameters

Babak O. Ya., Bashkirova A. D.
Abstract

Non-alcoholic fatty liver disease is the most common liver disease in the world, its prevalence is 25%, but it is even more widespread in different population groups and regions. The main causes of death among patients with non-alcoholic fatty liver disease are cardiovascular diseases. The common triggers of non-alcoholic fatty liver disease and hypertension are metabolic disorders which confirm the complex pathological links between these two nosologies. The purpose of the study was to examine the concentration of endothelial lipase, as the leading regulator of HDL concentration, in groups distributed by HDL levels, necessary for understanding the pathogenetic ration in patients with non-alcoholic fatty liver disease and hypertension. Material and methods. 50 patients with non-alcoholic fatty liver disease on the background of GB were examined. Patients were divided into groups according to indicators of HDL levels. All patients underwent general clinical studies, as well as the determination of serum endothelial lipase levels and the determination of the degree of steatosis using the non-alcoholic fatty liver disease liver fat score. Results and discussion. In patients with non-alcoholic fatty liver disease on the background of hypertension, HDL concentration depended on the available insulin resistance and was associated with alcohol consumption. Analysis of the lipid profile showed a significant (р < 0.05) difference between all groups in terms of HDL. The concentration of total cholesterol was not significantly different in groups. At the same time, the level of triglycerides and LDL in patients with high HDL levels was lower. It is interesting that the highest level of endothelial lipase is also fixed in this group. The severity of liver steatosis in terms of transaminase levels and steatosis index was significantly (р < 0.05) higher in individuals with low HDL levels. The highest insulin resistance was observed in individuals with low levels of HDL compared with those who have a protective concentration of them. Levels of LDL in patients with non-alcoholic fatty liver disease on the background of hypertension have a direct proportionality with total cholesterol concentration, body mass index and abdominal fat distribution and are associated with increased blood pressure. A regression analysis showed a reliable (p <0.05) positive correlation of the level of endothelial lipase with the concentration of total cholesterol and negative with the concentration of LDL. The study of dependences of the concentration of endothelial lipase with lipidogram indices revealed a positive relationship only with the level of total cholesterol and a negative one with the level of LDL. Conclusion. Thus, the concentration of endothelial lipase did not show a direct relationship with the level of HDL in the plasma, which highlights its additional role in LDL metabolism in conditions of liver steatosis against the background of insulin resistance.

Keywords: non-alcoholic fatty liver disease, hypertension, lipids, endothelial lipase, insulin resistance

Full text: PDF (Rus) 241K

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