ISSN 2415-3060 (print), ISSN 2522-4972 (online)
  • 3 of 44
JMBS 2019, 4(2): 21–26
Medicine. Reviews

Modern Aspects of Treatment of Depression

Kyselova A. A.1, Kravtsova E. S.2, Mishchenko D. O.2, Chernishova E. R.2

Nowadays depression is a very serious problem for modern society. It influences not only how a person feels, but also it can interference with his or her thoughts and behavior. Different life events such as stress at work, traumatic accident, divorce, and so on can lead to depression. According to the fifth edition of Diagnostic and Statistical Manual of Mental Disorders to be diagnosed with depression several symptoms (the most important of them are depressed mood and loss of pleasure and interest in life) must be present during at least 2 weeks. There are two main types of treatment of depression which are used in therapy. However, still it is not enough, and scientists have not stopped, and are continuing working on developing new methods of treatment. The aim of this article was to review articles, Internet sources, chapters from textbooks connected with the main topic of our article. All these materials were used to show the most common ways of treatment of depression and alternative methods, which are becoming very popular nowadays. The material of research was in 19 native and foreign sources (articles, Internet sources, chapters from textbooks) which are connected with the main theme of this article. Results and discussion. There are two main branches of treatment of depression. They are psychological treatment (which divides into interpersonal psychotherapy, cognitive therapy, cognitive-behavioral therapy, behavioral activation, behavioral couples therapy), and biological treatment (electroconvulsive therapy, medications, transcranial magnetic stimulation). Every method has its advantages and disadvantages; however, still we have those patients who are treatment-resistant. And at the moment scientists focus on these patients and try to administer new alternative method (such as ketamine, hatha yoga, acupuncture, psilocybin, and so on) to decrease the level of side effects.

Keywords: depression, medications, selective serotonin reuptake inhibitors, cognitive-behavioral therapy, interpersonal psychotherapy, behavioral activation, transcranial magnetic stimulation, ketamine

Full text: PDF (Eng) 176K

  1. Acupuncture combined with antidepressants can improve the treatment of depression, study finds [Internet]; 2019 [updated 2016 August 29]. Available from:
  2. Genetic analysis can help predict treatment response in depression, study finds [Internet]; 2019 [updated 2017 December 29]. Available from:
  3. Treating major depression with yoga: A prospective, randomized, controlled pilot trial [Internet]; 2019 [updated 2017 March 16]. Available from:
  4. Hatha yoga shows promise in the treatment of major depression [Internet]; 2019 [updated 2017 April 14]. Available from:
  5. Brain scans may help clinicians choose talk therapy or medication treatment for depression [Internet]; 2019 [updated 2017 March 26]. Available from:
  6. Teenagers could see long-term benefits from new treatments for depression [Internet]; 2019 [updated 2016 November 30]. Available from:
  7. Component of ketamine produces rapid improvement in treatment-resistant depression within just 2 hours [Internet]; 2019 [updated 2016 September 8]. Available from:
  8. Magic mushroom compound psilocybin can reduce symptoms of treatment-resistant depression [Internet]; 2019 [updated 2016 May 17]. Available from;
  9. Roseroot herb shows promise as potential depression treatment option [Internet]; 2019 [updated 2015 March 26]. Available from:
  10. Barlow DH, Durand VM, Abnormal Psychology. An integrative approach. 7th ed. USA, CA: Cengage Learning; 2015. p. 242-48.
  11. Kring AM, JoHnson SL, Davison GC, Neale JM. Abnormal Psychology. 13th ed. USA: Wiley Custom; 2017. p. 152-62.
  12. Laughing gas for depression? Nitrous oxide shows early promise as a potential treatment [Internet]; 2019 [updated 2014 December 9]. Available from:
  13. Nasal spray delivers new type of depression treatment [Internet]; 2019 [updated 2014 March 24]. Available from:
  14. Ketamine shows significant therapeutic benefit in people with treatment-resistant depression [Internet]; 2019 [updated 2013 May 18]. Available from:
  15. Types of treatment available for depression [Internet]; 2019 [updated 2018 January 25]. Available from:
  16. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders (DSM-5), Fifth edition. 2013.
  17. National Institute of Mental Health. (Data from 2013 National Survey on Drug Use and Health.). Available from:
  18. Kessler RC, Berglund P, Demler O, Jin R, Merikangas KR, Walters EE. Lifetime Prevalence and Age-of-Onset Distributions of DSM-IV Disorders in the National Comorbidity Survey Replication. Arch Gen Psychiatry. 2005; 62(6): 593-602.
  19. What is Depression? [Internet]; 2019 [updated 2017 January 15]. Available from: